Statistical mechanics of neocortical interactions: large-scale EEG influences on molecular processes

Recent calculations further supports the premise that large-scale synchronous firings of neurons may affect molecular processes. The context is scalp electroencephalography (EEG) during short-term memory (STM) tasks. The mechanism considered is $\mathbf{\Pi} = \mathbf{p} + q \mathbf{A}$ (SI units) coupling, where $\mathbf{p}$ is the momenta of free $\mathrm{Ca}^{2+}$ waves $q$ the charge of $\mathrm{Ca}^{2+}$ in units of the electron charge, and $\mathbf{A}$ the magnetic vector potential of current $\mathbf{I}$ from neuronal minicolumnar firings considered as wires, giving rise to EEG. Data has processed using multiple graphs to identify sections of data to which spline-Laplacian transformations are applied, to fit the statistical mechanics of neocortical interactions (SMNI) model to EEG data, sensitive to synaptic interactions subject to modification by $\mathrm{Ca}^{2+}$ waves.Comment: Accepted for publication in Journal of Theoretical Biolog

Statistical mechanics of neocortical interactions: EEG eigenfunctions of short-term memory

This paper focuses on how bottom-up neocortical models can be developed into eigenfunction expansions of probability distributions appropriate to describe short-term memory in the context of scalp EEG. The mathematics of eigenfunctions are similar to the top-down eigenfunctions developed by Nunez, albeit they have different physical manifestations. The bottom-up eigenfunctions are at the local mesocolumnar scale, whereas the top-down eigenfunctions are at the global regional scale. However, as described in several joint papers, our approaches have regions of substantial overlap, and future studies may expand top-down eigenfunctions into the bottom-up eigenfunctions, yielding a model of scalp EEG that is ultimately expressed in terms of columnar states of neocortical processing of attention and short-term memory.Comment: 5 PostScript page

Statistical mechanics of neocortical interactions: High resolution path-integral calculation of short-term memory

We present high-resolution path-integral calculations of a previously developed model of short-term memory in neocortex. These calculations, made possible with supercomputer resources, supplant similar calculations made in L. Ingber, Phys. Rev. E 49, 4652 (1994), and support coarser estimates made in L. Ingber, Phys. Rev. A 29, 3346 (1984). We also present a current experimental context for the relevance of these calculations using the approach of statistical mechanics of neocortical interactions, especially in the context of electroencephalographic data.Comment: 35 PostScript pages, including 14 figure

Optimization of Trading Physics Models of Markets

We describe an end-to-end real-time S&P futures trading system. Inner-shell stochastic nonlinear dynamic models are developed, and Canonical Momenta Indicators (CMI) are derived from a fitted Lagrangian used by outer-shell trading models dependent on these indicators. Recursive and adaptive optimization using Adaptive Simulated Annealing (ASA) is used for fitting parameters shared across these shells of dynamic and trading models

Forecasting COVID-19 with Importance-Sampling and Path-Integrals

Background Forecasting nonlinear stochastic systems most often is quite difficult without giving in to temptations to simply simplify models for the sake of permitting simple computations Objective Here two basic algorithms Adaptive Simulated Annealing ASA and path-integral codes PATHINT PATHTREE and their quantum generalizations qPATHINT qPATHTREE are suggested as being useful to fit COVID-19 data and to help predict spread or control of this pandemic Multiple variables are considered e g potentially including ethnicity population density obesity deprivation pollution race environmental temperature Method ASA and PATHINT PATHTREE have been demonstrated as being effective to forecast properties in three disparate disciplines in neuroscience financial markets and combat analysis Results Not only can selected systems in these three disciplines be aptly modeled but results of detailed calculations have led to new results and insights not previously obtaine